| Date | Opponent | Time/Result |
|
| Feb. 5, 2010 | Southwest Baptist (Mo.) | 6-2 W | Recap | Box |
| Feb. 6, 2010 | Southwest Baptist (Mo.) | 6-3 W | Recap | Box |
| Feb. 6, 2010 | Southwest Baptist (Mo.) | 8-5 W | Recap | Box |
| Feb. 12, 2010 | at Eastern New Mexico* | 6-5 W | Recap | Box |
| Feb. 12, 2010 | at Eastern New Mexico* | 13-14 L | Recap | Box |
| Feb. 13, 2010 | at Eastern New Mexico* | (9 inn.) 7-8 L | Recap | Box |
| Feb. 13, 2010 | at Eastern New Mexico* | 2-6 L | Recap | Box |
| Feb. 19, 2010 | at Northeastern State (Okla.)* | 7-4 W | Recap | Box |
| Feb. 19, 2010 | at Northeastern State (Okla.)* | 4-17 L | Recap | Box |
| Feb. 20, 2010 | at Northeastern State (Okla.)* | 6-2 W | Recap | Box |
| Feb. 20, 2010 | at Northeastern State (Okla.)* | 5-2 W | Recap | Box |
| Feb. 27, 2010 | Cameron (Okla.)* | 6-3 W | Recap | Box |
| Feb. 27, 2010 | Cameron (Okla.)* | 11-3 W | Recap | Box |
| Feb. 28, 2010 | Cameron (Okla.)* | 12-11 W | Recap | Box |
| Feb. 28, 2010 | Cameron (Okla.)* | 9-16 L | Recap | Box |
| Mar. 2, 2010 | Henderson State (Ark.) | 2-6 L | Recap | Box |
| Mar. 2, 2010 | Henderson State (Ark.) | 5-4 W | Recap | Box |
| Mar. 5, 2010 | at Tarleton State (Texas)* | 3-0 W | Recap | Box |
| Mar. 5, 2010 | at Tarleton State (Texas)* | 6-8 L | Recap | Box |
| Mar. 6, 2010 | at Tarleton State (Texas)* | 5-4 W | Recap | Box |
| Mar. 6, 2010 | at Tarleton State (Texas)* | 6-4 W | Recap | Box |
| Mar. 12, 2010 | Abilene Christian (Texas)* | 1-0 W | Recap | Box |
| Mar. 12, 2010 | Abilene Christian (Texas)* | 11-10 W | Recap | Box |
| Mar. 13, 2010 | Abilene Christian (Texas)* | 2-8 L | Recap | Box |
| Mar. 13, 2010 | Abilene Christian (Texas)* | (10 inn.) 10-9 W | Recap | Box |
| Mar. 16, 2010 | Oklahoma City | 6-8 L | Recap | Box |
| Mar. 19, 2010 | at Southwestern Oklahoma State* | 5-2 W | Recap | Box |
| Mar. 19, 2010 | at Southwestern Oklahoma State* | 15-4 W | Recap | Box |
| Mar. 26, 2010 | Central Oklahoma* | 9-5 W | Recap | Box |
| Mar. 27, 2010 | Central Oklahoma* | 2-6 L | Recap | Box |
| Mar. 27, 2010 | Central Oklahoma* | 6-3 W | Recap | Box |
| Mar. 28, 2010 | Central Oklahoma* | 15-14 W | Recap | Box |
| Mar. 30, 2010 | Southern Arkansas | 6-14 L | Recap | Box |
| Mar. 30, 2010 | Southern Arkansas | 9-22 L | Recap | Box |
| Apr. 3, 2010 | West Texas A&M* | 9-10 L | Recap | Box |
| Apr. 3, 2010 | West Texas A&M* | 9-6 W | Recap | Box |
| Apr. 4, 2010 | West Texas A&M* | (9 inn.) 4-6 L | Recap | Box |
| Apr. 4, 2010 | West Texas A&M* | 4-3 W | Recap | Box |
| Apr. 6, 2010 | at Henderson State (Ark.) | 1-3 L | Recap | Box |
| Apr. 6, 2010 | at Henderson State (Ark.) | (10 inn.) 11-8 W | Recap | Box |
| Apr. 9, 2010 | at Texas A&M-Kingsville* | 1-3 L | Recap | Box |
| Apr. 9, 2010 | at Texas A&M-Kingsville* | 3-11 L | Recap | Box |
| Apr. 10, 2010 | at Texas A&M-Kingsville* | 4-12 L | Recap | Box |
| Apr. 10, 2010 | at Texas A&M-Kingsville* | 13-5 W | Recap | Box |
| Apr. 16, 2010 | Angelo State (Texas)* | 4-3 W | Recap | Box |
| Apr. 16, 2010 | Angelo State (Texas)* | (10 inn.) 5-8 L | Recap | Box |
| Apr. 17, 2010 | Angelo State (Texas)* | 4-3 W | Recap | Box |
| Apr. 23, 2010 | at East Central (Okla.)* | 15-4 W | Recap | Box |
| Apr. 23, 2010 | at East Central (Okla.)* | 27-10 W | Recap | Box |
| Apr. 24, 2010 | at East Central (Okla.)* | 8-2 W | Recap | Box |
| Apr. 24, 2010 | at East Central (Okla.)* | 13-12 W | Recap | Box |
| May 1-4, 2010 | at Lone Star Conference Tournament | | Recap | Box |
| May 1, 2010 | Angelo State (Texas) | 10-23 L | Recap | Box |
| May 2, 2010 | vs. Tarleton State (Texas) | 2-6 L | Recap | Box |
